Synthetic Studies of Potential Antimetabolites. VII. Evidences that the supposed 1-β-D-Ribofuranosyl-1H-imidazo [4, 5-b] pyridine is actually 3-β-D-Ribofuranosyl-3H-imidazo [4, 5-b] pyridine (1-Deazapurine Ribofuranoside)
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چکیده
منابع مشابه
3-Ethyl-5-(4-methoxyphenoxy)-2-(pyridin-4-yl)-3H-imidazo[4,5-b]pyridine
In the title compound, C(20)H(18)N(4)O(2), the imidazopyridine fused ring system is almost perpendicular to the benzene ring [dihedral angle = 87.6 (5)°]. The pyridine ring makes a dihedral angle of 35.5 (5)° with the mean plane of the imidazopyridine fragment. The crystal structure is stabilized by an aromatic π-π stacking inter-action between the phenyl rings of neighbouring mol-ecules [centr...
متن کاملPharmacological Potential and Synthetic Approaches of Imidazo[4,5-b]pyridine and Imidazo[4,5-c]pyridine Derivatives.
The structural resemblance between the fused imidazopyridine heterocyclic ring system and purines has prompted biological investigations to assess their potential therapeutic significance. They are known to play a crucial role in numerous disease conditions. The discovery of their first bioactivity as GABAA receptor positive allosteric modulators divulged their medicinal potential. Proton pump ...
متن کامل8-Bromo-3,4-dihydro-2H-1,3-thiazino[2,3:2′,1′]imidazo[5′,4′-b]pyridine
The imidazopyridine ring system in the title compound, C(9)H(8)BrN(3)S, is almost planar [r.m.s. deviation of the C and N atoms = 0.007 (1) Å]. The S and methyl-ene C atoms connected to the five-membered ring lie within this plane. The remaining two methyl-ene groups of the thia-zine ring are disordered over two sets of sites in a 0.817 (5):0.183 (5) ratio.
متن کامل3-[(1-Benzyl-1H-1,2,3-triazol-5-yl)methyl]-6-bromo-2-phenyl-3H-imidazo[4,5-b]pyridine
There are two crystallographically independent mol-ecules in the asymmetric unit of the title compound, C(22)H(17)BrN(6). The dihedral angles between the imidazo[4,5-b]pyridine mean plane and the phenyl rings are 20.4 (2) and 24.0 (2)° in the two mol-ecules. The orientation of triazoles compared to the imidazo[4,5-b]pyridine system is almost the same in both mol-ecules, with dihedral angles of ...
متن کامل5-(4-Chlorophenyl)-1-methyl-3-phenyl-3,6,8,9-tetrahydropyrazolo[3,4-b]thiopyrano[4,3-d]pyridine
The title compound, C(22)H(18)ClN(3)S, was synthesized by the reaction of 4-chloro-benzaldehyde, tetra-hydro-thio-pyran-4-one and 3-methyl-1-phenyl-1H-pyrazol-5-amine in acetic acid without a catalyst. The pyridine and pyrazole rings are almost coplanar, the dihedral angle between their mean planes being 2.50 (1)°. The thio-pyran ring exhibits an envelope conformation. The crystal packing is st...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1963
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.11.265